Hogeschool van Amsterdam

Kenniscentrum Bewegen, Sport en Voeding



The European Society for Clinical Nutrition and Metabolism (ESPEN) encourages working groups to develop ESPEN guidelines. ESPEN guidelines have addressed the question of protein intake for different patients groups. However, most recommendations are only based on a low level of evidence and recommendations can be as diverse as 1-2 g/kg body weight.

scientific literature

Recently, optimal protein intake in relation to health outcomes has been subjected to a systematic literature review for the healthy adult and elderly population. The relationship between protein intake and health outcomes in hospitalized patients remains unclear.


The aim of the PROSYST project is to assess the evidence behind an optimal protein intake in hospitalized patients, either based on nitrogen balance studies,  protein turnover tracer studies, or outcome based studies of prospective cohort studies, case-control studies, and randomized controlled trials.


A systematic literare review will be performed following the guideline for conducting systematic literature reviews for the 5 th edition of the Nordic Nutrition Recommendations.
The key characteristics of the review process are:

  • The definition of the research questions to be answered;
  • The definition of the eligibility criteria;
  • A systematic search that attempts to identify all studies that meet the eligibility criteria;
  • A systematic selection and evaluation of the included papers;
  • The construction of summary tables of the studies;
  • Rating the evidence and formulate conclusions.


The intended result of the project is to support the ESPEN disease specific guidelines concerning the paragraph of protein requirements for the hospitalized patient group.


-Peter Weijs, Professor Weight Management and Professor Nutrition and Exercise, with special reference to Protein
-Martinet Streppel, project coordinator 

In collaboration with an international consortium of protein experts:

-Professor Jens Kondrup, Rigshospitalet University Hospital, Copenhagen, Denmark 
-Professor Gianni Biolo, University of Trieste, Trieste, Italy 
-Professor Yves Boirie, Centre Hospitalier Universitaire, Clermont-Ferrand, France 
-Professor Olav Rooijackers, Karolinska University Hospital, Stockholm, Sweden

For more information contact Martinet Streppel: m.t.streppel@hva.nl



Gepubliceerd door  Kenniscentrum Bewegen, Sport en Voeding 12 september 2018