Hogeschool van Amsterdam

Urban Vitality



The European Society for Clinical Nutrition and Metabolism (ESPEN) encourages working groups to develop ESPEN guidelines. ESPEN guidelines have addressed the question of protein intake for different patients groups. However, most recommendations are only based on a low level of evidence and recommendations can be as diverse as 1-2 g/kg body weight.

Recently, optimal protein intake in relation to health outcomes has been subjected to a systematic literature review for the healthy adult and elderly population. The relationship between protein intake and health outcomes in hospitalized patients remains unclear.


The aim of the PROSYST project is to assess the evidence behind an optimal protein intake in hospitalised patients, either based on nitrogen balance studies, protein turnover tracer studies, or outcome based studies of prospective cohort studies, case-control studies, and randomized controlled trials.


A systematic literature review will be performed following the guideline for conducting systematic literature reviews for the 5th edition of the Nordic Nutrition Recommendations.
The key characteristics of the review process are:

  • The definition of the research questions to be answered;
  • The definition of the eligibility criteria;
  • A systematic search that attempts to identify all studies that meet the eligibility criteria;
  • A systematic selection and evaluation of the included papers;
  • The construction of summary tables of the studies;
  • Rating the evidence and formulate conclusions.


The intended result of the project is to support the ESPEN disease specific guidelines concerning the paragraph of protein requirements for the hospitalised patient group.


  • Peter Weijs, Professor Nutrition and Exercise, with special reference to Protein
  • Michael Tieland, project coordinator

In collaboration with an international consortium of protein experts:

  • Professor Jens Kondrup, Rigshospitalet University Hospital, Copenhagen, Denmark
  • Professor Gianni Biolo, University of Trieste, Trieste, Italy
  • Professor Yves Boirie, Centre Hospitalier Universitaire, Clermont-Ferrand, France
  • Professor Olav Rooijackers, Karolinska University Hospital, Stockholm, Sweden

For more information please contact Michael Tieland.

Gepubliceerd door  Urban Vitality 22 november 2019

Project Info

Startdatum 01 okt 2014
Einddatum 01 jan 2021


Dr. Meurerhuis (DMH)

Dr. Meurerlaan 8

1067 SM Amsterdam

020 595 3400